Multiple Sclerosis and Pregnancy

What is multiple sclerosis?

Multiple sclerosis (MS) is a chronic disease of the central nervous system, which is made up of the brain and spinal cord. MS is unpredictable. It can range from benign to disabling. Some people with MS may be mildly affected. Others may lose the ability to write, speak, or walk.


What causes multiple sclerosis?

Many things may cause MS, including viruses, autoimmune disorders, environmental factors, and genetic factors. But all of the possible causes share a common feature. The body's immune system attacks its own nervous tissue. In MS, the immune system attacks the layer of protein called myelin that surrounds the nerve fibers in the central nervous system. Myelin insulates the electrical signals the nervous system uses to communicate. When this insulation is destroyed, communication is interrupted. Parts of the nervous system become permanently damaged.


What are the symptoms of multiple sclerosis?

Symptoms of MS are erratic. They may be mild or severe. They may last a short or long time. They may appear in various combinations, depending on the part of the nervous system affected. Throughout the course of the illness, you may have any or all of these symptoms:

  • Muscle weakness in the arms and legs
  • Trouble with coordination
  • Impaired walking or standing
  • Partial or complete paralysis
  • Spasticity (involuntary increased tone of muscles leading to stiffness and spasms)
  • Fatigue (may be triggered by physical activity, may ease with rest, or may be constant and persistent)
  • Loss of sensation, tingling or numbness
  • Speech problems
  • Tremor
  • Dizziness
  • Hearing loss
  • Loss of vision or changes in vision
  • Loss of bowel and bladder control
  • Sexual dysfunction
  • Pain
  • Emotional changes
  • Changes in reflexes

MS may also cause cognitive effects. The effects may be mild. They are often found only after thorough testing. They may include problems with:

  • Concentration
  • Attention
  • Memory
  • Judgment

The symptoms of MS may look like other health problems. Always see your healthcare provider for a diagnosis.

How is multiple sclerosis diagnosed?

Your healthcare provider will do a thorough medical history and a physical exam as the first steps toward diagnosis of MS. You will be asked about all of your symptoms, how often they occur and how long they last.

You will likely have an MRI (magnetic resonance imaging) scan. This test can detect the unique scars in the central nervous system.

In some cases, you may need lab tests or a lumbar puncture to confirm the diagnosis.

How is multiple sclerosis treated?

There is no cure for MS. But there are disease-modifying therapies available that can slow the progression of the disease and improve symptoms. These include:

  • Beta-interferons
  • Glatiramer acetate
  • Monoclonal antibodies
  • Dimethyl fumarate
  • Fingolimod
  • Teriflunomide

There are also treatments to help manage symptoms, treat flare-ups or relapses, improve your function and safety, and provide much needed emotional support. The following

rehabilitation therapies may also help:

  • Physical therapy
  • Occupational therapy
  • Speech and swallowing assistance
  • Cognitive therapy
  • Assistive devices like splints

Living with multiple sclerosis while pregnant

Fortunately, pregnancy does not appear to speed up the course or worsen the effects of MS. Several studies suggest that MS is less likely to flare up late in pregnancy. But there is a slightly higher risk right after pregnancy.


The disabling effects of the disease may make it physically hard to carry a pregnancy. Muscle weakness and coordination problems may increase the likelihood for falls. Fatigue may worsen. Wheelchair dependence may increase the risk for urinary tract infections. There is no evidence that MS causes infertility. Studies have shown that pregnancy, delivery, and rate of birth defects are not majorly different in women with MS compared with those without MS. 

Many of the medicines used to treat MS may have adverse effects on a fetus. It is important to talk with your healthcare provider if you are thinking about pregnancy or if you become pregnant. Your healthcare provider will discuss the risks and benefits of the various medicines with you, including any possible effects on your baby and your MS.

During pregnancy, you will need close monitoring to keep track of the disease and the health of the fetus. You may need more frequent prenatal visits. There is no established treatment that alters the course of MS. But you may be given medicines such as steroids and anti-inflammatory drugs. Consult your healthcare provider for more information.

Supportive treatment and rehabilitation for MS are especially important during pregnancy. Rehab varies depending on your symptoms. But it may help with the following:

  • Doing normal activities of daily living (ADLs)
  • Maintaining independence
  • Getting family involved
  • Using assistive devices (for example, canes, braces, and walkers)
  • Setting an appropriate exercise program to promote muscle strength, endurance, and control
  • Re-establishing motor skills
  • Improving communication skills if you have trouble speaking because of weakness or lack of coordination of face and tongue muscles
  • Managing bowel or bladder incontinence
  • Providing cognitive retraining
  • Adapting the home environment for safety and usability

During labor, you may not have pelvic sensation, and you may not feel pain with contractions. This may also make it hard to tell when labor starts. Delivery of the baby may be harder if you have MS. While labor itself is not affected, MS can affect the muscles and nerves needed for pushing. For this reason, you may need a cesarean section or delivery with the help of forceps or vacuum.

Online Medical Reviewer: Joseph Campellone MD

Online Medical Reviewer: Anne Fetterman RN BSN

Online Medical Reviewer: Raymond Kent Turley BSN MSN RN

Date Last Reviewed: 3/1/2019

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